… Amiloride exerts its clinical effects through inhibition of renal epithelial sodium channels (ENaC),
[18… Structure–activity relationships (SAR) of amiloride analogs against NHE1 have been …

… by increased absorption via ENaC epithelial sodium channel. The dehydration of the liquid
… SPX-101 is a novel epithelial sodium channel-targeted therapeutic for cystic fibrosis that …

… The urokinase plasminogen activator (uPA) is a widely studied anticancer drug target with
multiple classes of inhibitors reported to date. Many of these inhibitors contain amidine or …

… In summary, we have systematically studied a novel approach to construct 3-benzyl-2,5-diarylpyrazine
derivatives using arylaldehydes and α-amino ketones as the starting materials. …

… Recently, novel genetic engineering methods like CRISPR/Cas9 and TALEN have … treatment
strategies. The main part of this article provides a comprehensive overview of cystic fibrosis …

… Cystic fibrosis … channel, ORCC) … (Atypical Cystic Fibrosis) …